Persistent pain model reveals sex difference in morphine potency

Persistent pain model reveals sex difference in morphine potency.

Central or systemic administration of agonists directed at the mu or delta opiate receptors generally produce a greater degree of analgesia in males than in females. To date, most studies examining sex-based differences in opioid analgesia have used acute noxious stimuli (i.e., tail-flick and hot plate test); thus the potential dimorphic response of centrally acting opiates in the alleviation o...

PERSISTENT PAIN MODEL REVEALS SEX DIFFERENCE IN MORPHINE POTENCY Running Head: Sex differences in morphine analgesia

CALL FOR PAPERS Sex and Gender Differences in Pain and Inflammation Persistent pain model reveals sex difference in morphine potency

peripherally mediated Sex differences in morphine-induced analgesia of visceral pain are supraspinally and including high-resolution figures, can be found at: Updated information and services ranging from molecules to humans, including clinical investigations. It is published 12 times a year (monthly) by the American illuminate normal or abnormal regulation and integration of physiological mech...

Sex Differences in Peripheral Mu-Opioid Receptor Mediated Analgesia in Rat Orofacial Persistent Pain Model

Unilateral ligation of the tendon of anterior superficial part of rat masseter muscle (TASM) leads to long-lasting allodynia. Sex differences in peripheral mu-opioid receptor (MOR)-mediated analgesia under persistent myogenic pain are not well understood. In this study, we examined (1) whether locally applied MOR agonists attenuate persistent pain following TASM ligation in a sex dependent mann...

Introduction: Sex makes a difference: experimental and clinical pain responses.

In exploration, large discoveries precede smaller ones. In the case of geographic exploration, large landmasses were found and then, eventually, bays, rivers, and creeks were identified and mapped. Much the same process occurred in the case of scientific exploration. With the passage of time, broad principles were refined and exceptions led the way to new rules. It was necessary, to discern the...